Toronto Stock Exchange Symbol: SXC

SYSTEMS XCELLENCE TO HOST CONFERENCE CALL TO DISCUSS CALENDAR YEAR 2004 THIRD QUARTER RESULTS

- Results to be released at 7:00am on Thursday, November 4th -

MILTON, Ontario - October 25, 2004, Systems Xcellence Inc., (TSX: SXC) will be holding a conference call to discuss its calendar year 2004 third quarter financial results. Mr. Gordon Glenn, President and Chief Executive Officer will be hosting the call.

DATE: Thursday, November 4, 2004

TIME: 8:30 am, Eastern Standard Time

DIAL IN NUMBER: 416-405-8532 or 1-877-295-2825

TAPED REPLAY: 416-695-5800 or 1-800-408-3053
Available until November 11, 2004

REFERENCE NUMBER: 3107390

WEBCAST: A live audio webcast of the call will be available at www.sxc.com and www.financialdisclosure.ca.

Webcast attendees are welcome to listen to the conference in real-time or on-demand at your convenience. The webcast will be archived for 90 days.

Please connect to this website at least 15 minutes prior to the conference call to ensure adequate time for any software download that may be needed to hear the webcast.

About Systems Xcellence Inc.

Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Scottsdale, Arizona and Victoria, British Columbia. SXC is a leading provider of healthcare information technology solutions and services to the healthcare benefits management industry. The company's product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, retail pharmacy chains and other healthcare intermediaries. SXC can be found on the Internet at www.sxc.com.

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Management Discussion and Analysis published in the Company's annual report.

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