Toronto Stock Exchange Symbol: SXC

Systems Xcellence to provide InformedRx pharmacy benefit administration services for two new clients

MILTON, Ontario February 1, 2005, Systems Xcellence Inc., ("SXC" or the "Company") (TSX: SXC) a leading provider of healthcare information technology solutions throughout the pharmaceutical supply chain, today announced the sale of its InformedRx pharmacy benefit administration services through its U.S. subsidiary, SXC Health Solutions, Inc., to a regional Pharmacy Benefit Manager ("PBM") based in Massachusetts, and a Managed Care Organization ("MCO") based in New York City. The contracts have a combined value of approximately $800,000 over three years with significant upside potential, and are expected to go-live during the second quarter of 2005. All figures are in U.S. dollars, unless otherwise noted.

"Building our base of InformedRx customers is a key component of our growth strategy in the healthcare payer marketplace and will help to increase our revenue earned from recurring sources," said Gordon S. Glenn, President and CEO of SXC. "Our pipeline of opportunities continues to expand as InformedRx addresses the key issues facing our payer clients, namely the need for better drug price transparency, greater control over drug formulary plans, and seamless and integrated access to the vast network of pharmacies located across the U.S. Ultimately our ability to deliver these solutions allows our customers to better manage and reduce the cost associated with the delivery of prescription drug benefits to their health plan members."

The MCO and PBM will use InformedRx to design healthcare benefit plans for its members, adjudicate prescription drug claims, manage reimbursement of retail pharmacy network contracts, analyze drug utilization, and establish a web portal to extend the point-of-contact with their members. In addition, the PBM will use InformedRx to manage rebate contracts with pharmaceutical manufacturers.

"These contracts demonstrate the broad appeal and flexibility of InformedRx as the PBM is an established organization with more than 200,000 members that has selected SXC to replace its incumbent provider, while the MCO is looking to utilize our solutions in order to participate in the U.S. government-sponsored Medicare Part D pharmacy benefit program," added Mr. Glenn. "In the initial stages of our agreement with the PBM, we will provide the transaction processing for a portion of their membership with an opportunity to expand the scope of our agreement over time."

About InformedRx
InformedRx is a broad suite of à la carte pharmacy benefit administrative services that provide a flexible and cost-effective alternative to traditional pharmacy benefit management offerings typically employed by managed care organizations. InformedRx is built around SXC's industry leading pharmacy claims processing system, RxCLAIM® and features pricing on a fee-for-service basis. RxCLAIM is a transaction processing system designed to provide instant on-line adjudication of third party prescription drug claims at the point of service, including trouble-free claims management and cost-effective review, as well as payment and billing support and real-time functionality for updating benefit, price, member, provider and drug details.

About Systems Xcellence Inc.
Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Warminster, Pennsylvania, Scottsdale, Arizona and Victoria, British Columbia.  Through its SXC Health Solutions, Inc subsidiary, SXC is a leading provider of healthcare information technology solutions and services to the U.S. healthcare benefits management industry. The company's product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, independent, chain and mail-order pharmacies and other healthcare intermediaries.  SXC can be found on the Internet at www.sxc.com.

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Company's Annual Information Form.


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