Toronto Stock Exchange Symbol: SXC

Systems Xcellence HOSTS ANNUAL AND SPECIAL MEETING OF SHAREHOLDERS - 
MAY 11, 2005

MILTON, ON, May 10 - Systems Xcellence Inc., ("SXC") (TSX: SXC) a leading provider of healthcare information technology solutions throughout the pharmaceutical supply chain, will be holding its Annual and Special Meeting of Shareholders on May 11th, 2005 at the Sheraton Centre Hotel Toronto, The City Hall Room, 123 Queen Street West, Toronto, Ontario. The meeting will begin at 4:30 p.m.

If you are unable to attend the meeting, a live audio version will be available on the Internet at www.sxc.com. A replay of the Annual Meeting of Shareholders will also be archived at www.sxc.com for 365 days.

About Systems Xcellence Inc.

Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Warminster, Pennsylvania, Scottsdale, Arizona and Victoria, British Columbia.  Through its SXC Health Solutions, Inc subsidiary, SXC is a leading provider of healthcare information technology solutions and services to the U.S. healthcare benefits management industry. The company’s product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, independent, chain and mail-order pharmacies and other healthcare intermediaries.  SXC can be found on the Internet at www.sxc.com.

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Company's Annual Information Form.

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