Systems Xcellence Announces $3.5 Million Contract for its HBS Pharmacy Software and Services

Warminster, PA September 28, 2005, Health Business Systems, Inc. (“HBS”), a wholly-owned subsidiary of Systems Xcellence Inc. (“SXC”) (TSX: SXC), a leading provider of pharmacy management systems, announces an agreement to provide licensed software, support and maintenance services to a 62-store supermarket pharmacy chain (the “Chain”) based in the southern U.S. Under the terms of the agreement the Chain will purchase all related hardware, software licenses, and implementation services from HBS. In addition, the maintenance agreement includes bundled services for software support, clinical updates and transaction switching services.

"This contract reinforces our commitment to the retail chain market," said Gordon S. Glenn, President and CEO, SXC. “Our market strategy for the retail provider market is currently focused on regional and midsize chains that tend to average around 50 – 1,500 stores. We believe that the strongest and most profitable opportunities lie in this expanding yet underserved segment of the market.”

"HBS' proven pharmacy management functionality combined with real-time centralized management and off-line redundancy, is unique in this industry and allows retail chains to provide the highest level of service with reliability in all situations," added Louis Greenberg, President, HBS.

HBS’ solution will create a centralized database for all stores allowing the Chain’s head office to view and manage store-wide data including, claim reconciliation and management of patient and corporate accounting information. The HBS Pharmacy Management system will enable the Chain to centrally manage its growing business services, while allowing the stores to implement workflow solutions designed to increase productivity and enhance service in the pharmacy.

The corporate systems implementation is expected to begin in the first quarter of 2006 with store implementations continuing into the fourth quarter of 2006.

About Systems Xcellence Inc.

Systems Xcellence (SXC) is headquartered in Milton, Ontario with offices and processing centres in Lombard, Illinois, Warminster, Pennsylvania, Scottsdale, Arizona and Victoria, British Columbia.  Through its SXC Health Solutions, Inc subsidiary, SXC is a leading provider of healthcare information technology solutions and services to the U.S. healthcare benefits management industry. The company’s product offerings and solutions combine a wide range of software applications, application service provider (ASP) processing services and professional services, designed for many of the largest organizations in the pharmaceutical supply chain, such as pharmacy benefit managers, managed care organizations, independent, chain and mail-order pharmacies and other healthcare intermediaries. SXC can be found on the Internet at www.sxc.com.

This press release contains forward-looking statements based on current expectations. These forward-looking statements entail various risks and uncertainties that could cause actual results to differ materially from those reflected in these forward-looking statements. Risks and uncertainties about the Company's business are more fully discussed in the Company's Annual Information Form.